FBB December 2018 – Newsletter

December 2018 – Newsletter
This month of December will beautifully close 2018 with 2 featured companies:
Aspen Biosciences, who is launching a new comprehensive tool for a through exploration of the Biotech market, called Pharm2Market.
And the in Vivo division of PerkinElmer, with the IVIS in vivo imaging systems and Quantum microCT imaging systems, which are best in class preclinical instruments for robust translational research.
Companies of the month
Aspen Biosciences

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Aspen Biosciences – Pharm2Market

Aspen Biosciences is a research informatics company which provides software and services to support drug discovery organizations. Some of our previous projects include custom target-, assay-, and compound-management systems designed to meet the unique needs of our customers. We also provide technology selection and implementation services for electronic lab notebook (eLN), and Lab Information Management Systems (LIMS). We have experience implementing systems to support a variety of therapeutic classes including small molecule, antibodies & peptides, and cell-based therapeutics.
Pipeline – Drug Discovery Portfolio & Project Management
Over the years we’ve had frequent requests for help developing or integrating project management tools. The challenge for most pharmaceutical companies has been that off-the-shelf applications in this space lack direct support for the science behind drug discovery projects. Tools like Microsoft Project, Jira, SmartSheet, and Asana lack support for target, pathway and literature information. They have no support for meeting and decision tracking, and lack support for lessons learned. To address that, we’ve distilled conversations with dozens of project and scientific portfolio managers in biotech and pharmaceutical companies into a cloud-based application called Pipeline.
Pipeline helps drug discovery companies answer questions like, “What drug targets and pathways are we working on”, “What is their role in a given disease”, “What recent discoveries have been made (literature searching)”, “Who’s working on the project (project tracking & dashboarding)”, “What tasks are they performing”, “What’s the current status of the project”, “Where are the results from that cell-based assay we screened last month”, “How is this project similar to the project we worked on 5 years ago”, “What did we learn from this project”, “What lessons did we learn from previous projects that we can apply to this project”.

Pharm2Market – Connecting Drug Discovery Communities
Pharm2Market is a new service that we’re launching to connect drug discovery startups to news, investors, partners and services to help advance their drug discovery programs.
If you’re a founder, Pharm2Market can help you find investors, partners and services in your area. We also help you find the resources, everything from finding legal advice on company formation and IP, to finding lab space, lab instrumentation and reagents. We also connect you with resources like the French Bio Beach, and San Diego Venture Group to help expand your network and keep track of all the local networking and conference opportunities.
If you’re a business development professional, Pharm2Market contains information on over 200 local drug discovery companies. We track the projects, targets, therapeutic areas and therapeutic classes, pathways, and clinical trials that companies are involved in. This makes it easier for you to identify potential partnering and licensing opportunities.
If your company provides lab space, construction or facilities services, you can use Pharm2Market to identify companies in need of expanded lab space, or lab remodels. If you provide contract research or manufacturing services, Pharm2Market can help you identify customers with Phase 2 and 3 projects who need your services in order to complete their clinical trials.

To learn more about us or start a conversation, visit us on our web site, or reach out to us on social media:
Twitter: @AspenBio @Pharm2Market
Email: info@aspenbiosciences.com


PerkinElmer In Vivo Imaging
Image Caption: “IVIS Spectrum 3D bioluminescence reconstruction shows precise localization of GL261-luc2 brain tumor using digital organ map.”

PerkinElmer Inc, through its Discovery & Analytical Solutions business segment, provides a suite of in vivo imaging solutions (IVIS) comprising reagents, software and instrumentation.  This powerful suite of tools allows researchers to visualize cellular and biological functions as well as anatomical and physiologic changes non-invasively in whole, live animals. 

Optical imaging
PerkinElmer’s IVIS instrument platform boasts several models each with somewhat different features and benefits and each designed to fit within almost any research budget.

PerkinElmer’s flagship IVIS instrument is the IVIS Spectrum.  The Spectrum is the most advanced optical imaging system on the market combining high throughput (2D) optical imaging and full tomographic (3D) optical imaging in one platform.  The IVIS Spectrum is capable of ultra-sensitive bioluminescent and fluorescent imaging.  Bioluminescent sensitivity is achieved by using a cooled (-90ºC) camera with large CCD chip area and low F-stop.  With an exquisite signal-to-noise ratio (SNR) better than any other instrument on the market, the IVIS Spectrum has even been shown capable of detecting as few as five cells subcutaneously in nude mice.  For fluorescence applications, the IVIS Spectrum employs an optimized set of high efficiency filters (400nm to 900nm) and patented spectral unmixing software algorithms which grant researchers the ability to image and quantify all commonly used fluorophores, including fluorescent proteins, dyes and conjugates. 
Going beyond just 2D imaging, full tomographic (3D) optical imaging can also be achieved with the IVIS Spectrum.  This allows researchers to analyze 3D sources in an anatomical context and quantify the of number of cells and/or the dye concentration.  Additionally, the 3D optical data can be co-registered with other tomographic technologies such as MR, PET or CT through PerkinElmer’s LivingImage multimodality software module.
MicroCT Imaging
Preserving the historical sweet spot of microCT imaging, PerkinElmer’s Quantum GX2, is an excellent imager for studying bone in exquisite detail.  But, thanks to its unique flat panel CMOS detector and its cardiac and respiratory gating tools, the Quantum GX2 also excels at providing functional information, such as cardiac function estimation or perfusion, as well as other soft tissue applications.
Image Caption: “Quantum GX2 image of a mouse heart scanned using a four minute gated scan with CT contrast.”
As previously mentioned, microCT has historically and primarily been used as a tool for capturing bone and skeletal image data, but bone data analysis was tedious and cumbersome.  To rectify this, scientists at PerkinElmer built AccuCT—a one-of-a-kind advanced, automated bone analysis software tool.  Designed to automatically segment bones and perform ASBMR morphometric analysis, AccuCT enables researchers at all levels of experience to perform advanced bone analysis in a user-friendly workflow-based software package.  In addition to facilitating data analysis, AccuCT’s 3D rendering capabilities produce high impact images for manuscripts and presentations with just a few mouse clicks. 
Image Caption: “AccuCT from PerkinElmer automates bone identification, segmentation and analysis.”
Through its advances in optical imaging and innovation with microCT imaging, PerkinElmer continues to open new doors for academic researchers and industry scientists alike.  Optical image data and microCT data can even be co-registered to better understand disease nuances in all its dimensions.
To learn more about how in vivo imaging can help advance your research please contact your in vivo imaging specialist, Marc Guerra, at (619) 302-8405 or marc.guerra@perkinelmer.com

Next Breakfast Event
Because you are already sweet enough!
Considering the significant increase of sugar consumption and commitments during the period of Christmas and New Year, the FBB committee board will hold on the Breakfast networking event until February.


Happy Hour Networking Event
bella vista social club & caffe
December 14th
from 5pm to 7pm (PST)
Celebrating the end of the year. Come to tell us about your 2018 achievements and plan your 2019 expectations with a drink together.
Social Activity
Last chance to get your voice heard if you want to promote your favorite activities.
First round of activity would open on Sunday, January 20, 2019 (10am-12pm).
For now, six activities are leading the way: Hike, Surf, Pool (billiard), SUP/Kayak, Snorkeling, Tennis.


Local News/Events
Professional opportunities
Antibody Design Labs is recruiting!
We are looking for a part-time Office Assistant at our new location. The person will be in charge of diverse office clerk duties including helping with shipping and receiving, ordering and maintaining supply, managing files, recording information, greeting clients and visitors and coordinating team work and communication, among others. A strong organizational skill is welcome.
Please send inquiry with resume at:  support@abdesignlabs.com
We wish you happy holidays and hope to see you at our events!
Kevin Adam, Beatrice David Shevlin and Stephane Richard of the French BioBeach team
Follow our events and share to your friends/colleagues


Thank You to our SPONSORS
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