Cypre, Inc. has developed a simple 3D cell culture platform and tested protocols enabling scientists to assay complex tumor biology, including ex vivo (patient, PDX, mouse), tumor-stromal and tumor-immune coculture studies.
VersaGel® is our proprietary, biocompatible 3D matrix that has the benefits of a hydrogel with the functional relevance of an extracellular matrix (ECM). Its design allows for cellular adhesion (through integrin binding sites, e.g. RGD), tumor and immune cell invasion, and MMP-degradation, mimicking the multiple phases of tumor progression. VersaGel-Immunology is optimized for immune cell infiltration assays and VersaGel-Oncology, used in solid tumor assays, comes in three formulations for different growth conditions of various tumor cell types – Soft, Standard, Stiff. VersaGel is amenable to various methods of analysis, including high content imaging, plate reading, and flow cytometry following a 30-minute matrix digestion.
Symphony® is our patented one-button instrument that solidifies VersaGel in microwell plates in 60 seconds. Symphony-24 and Symphony-96 are specifically designed for 24-well and 96-well plates respectively. Not much wider than a microtiter plate, the Symphony’s small footprint allows it to easily fit in your bio-safety cabinet further streamlining your workflow.
Contact Robert Lynde (firstname.lastname@example.org
) to learn more about our demo program.
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